Bone Mechanoregulation During Growth
Understanding how mechanical forces guide skeletal growth and adaptation.
This NSERC-funded project investigates how mechanical forces influence bone growth, from cellular-level changes to whole-bone development. While mechanical regulation of adult bone remodelling has been more extensively studied, much less is known about how mechanical stresses influence bone growth.
Our lab uses an experimental murine tibia loading model, microCT imaging, histological and cellular-level analyses, and mechanical assessment to study how the growing skeleton responds to its physical environment.
Methods
- Murine tibia loading
- microCT imaging
- Histology
- Cellular-level analysis
- Mechanical assessment
Opportunities
This project is actively seeking graduate and undergraduate honours students across backgrounds spanning biomedical sciences, biomechanics, and engineering. Students on this project gain hands-on training in bone biology, experimental biomechanics, imaging, and tissue-level analysis while contributing to a deeper understanding of how mechanical forces guide skeletal growth and adaptation.