Advanced Imaging to Monitor Juvenile Idiopathic Arthritis

Multimodal imaging of joint damage and growing bone in pediatric arthritis.

Juvenile idiopathic arthritis (JIA) affects bone development and joint health in children and adolescents, but its cause and progression are unpredictable. Our lab uses multimodal imaging to study changes in bone microarchitecture and the development of bone erosions, with the goal of detecting joint damage earlier and understanding how it progresses over time.

By comparing novel high-resolution imaging with conventional clinical imaging, we aim to improve the diagnosis, monitoring, and treatment of JIA while gaining new insights into how inflammatory arthritis affects the growing skeleton. This project aims to identify imaging biomarkers that can improve how joint health and bone development are monitored in children and adolescents with inflammatory arthritis.

Clinical ultrasound imaging in a pediatric arthritis study

Project Details

Related selected publication: Carpal bone segmentation for HR-pQCT imaging.

Improved segmentation accuracy in high-resolution peripheral quantitative computed tomography scans of carpal bones using adaptive local thresholding.
MT Kuczynski, S Poncioni, S Elmahdy, E Baldesarra, P Zysset, SL Manske, DE Whittier
JBMR Plus  ·  30 Mar 2026  ·  pubmed:42124860

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