Research

Our work connects clinical imaging and preclinical bone mechanobiology to understand how growing bones develop, adapt, and recover.

Research Pillars

Clinical Research Pediatric cohorts, fracture healing, obesity, and JIA imaging. Preclinical Research Experimental models of bone mechanobiology during growth. Imaging & Infrastructure Imaging platforms, analysis workflows, and computational tools.

Projects

Bone mechanoregulation during growth
Bone mechanoregulation during growth Preclinical bone mechanobiology

This NSERC-funded project investigates how mechanical forces influence bone growth, from cellular-level changes to whole-bone development.

preclinical biomechanics bone-growth
In vivo assessment of pediatric fracture healing
In vivo assessment of pediatric fracture healing Longitudinal imaging of bone repair during growth

This SickKids ECR Operating Grant-funded project investigates how bone repairs itself during pubertal growth following fracture and why healing differs between individuals.

clinical fracture-healing hr-pqct
The impact of childhood obesity on bone strength and growth
The impact of childhood obesity on bone strength and growth Imaging and modelling bone adaptation in children and adolescents

This project uses advanced musculoskeletal imaging and computational modelling to study why children with obesity can have elevated fracture risk despite higher bone mineral density.

clinical computation obesity
Advanced imaging to monitor juvenile idiopathic arthritis
Advanced imaging to monitor juvenile idiopathic arthritis Earlier insight into joint damage and growing bone

This project uses multimodal imaging to study bone microarchitecture and erosions in juvenile idiopathic arthritis, with the goal of improving diagnosis, monitoring, and treatment.

clinical arthritis multimodal-imaging